Open AccessPrevalence in Cryptococcus neoformans strains of a polysaccharide epitope which can elicit protective antibodies
Author(s) -
Wendy Cleare,
Shaibal Mukherjee,
Eric D. Spitzer,
Arturo Casadevall
Publication year - 1994
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.1.6.737-740.1994
Subject(s) - cryptococcus neoformans , epitope , monoclonal antibody , microbiology and biotechnology , antibody , biology , agglutination (biology) , phagocytosis , cryptococcus , immunofluorescence , virology , cryptococcosis , immunology
Monoclonal antibody (MAb) 2H1 binds to an epitope in the capsule of Cryptococcus neoformans that can elicit protective antibodies. The binding of MAb 2H1 to C. neoformans strains was studied by agglutination, immunofluorescence, and phagocytosis assays. The MAb 2H1 epitope was present in all 21 isolates studied, including those recovered from patients with recurrent infections.