Open AccessAcute monocytic leukemia in a dog with X-linked severe combined immunodeficiency
Author(s) -
Peter J. Felsburg,
Richard L. Somberg,
G. S. Krakowka
Publication year - 1994
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.1.4.379-384.1994
Subject(s) - acute monocytic leukemia , severe combined immunodeficiency , leukemia , acute leukemia , malignancy , immunodeficiency , monocytic leukemia , medicine , virology , immunology , biology , immune system , gene , biochemistry
We describe the occurrence of acute monocytic leukemia in a dog with X-linked severe combined immunodeficiency (XSCID) that had been raised in a gnotobiotic environment for 20 months. This case represents the first reported instance of malignancy in canine XSCID, the first case of acute monocytic leukemia in any species with severe combined immunodeficiency, and the first documented malignancy in any species with XSCID that was not associated with immunotherapy.