Open AccessEnriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis
Author(s) -
V.R. Bonagura,
Frederick P. Siegal,
Allan L. Abramson,
Frances SantiagoSchwarz,
Mary Ellen O’Reilly,
K M Shah,
Domenica Drake,
Bettie M. Steinberg
Publication year - 1994
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.1.3.357-360.1994
Subject(s) - immunology , major histocompatibility complex , human leukocyte antigen , recurrent respiratory papillomatosis , immune system , phenotype , biology , antigen , mhc class i , mhc class ii , minor histocompatibility antigen , papilloma , medicine , gene , genetics , pathology
Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate papillomavirus evasion of the cellular immune response.