Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis | Zendy

Vincent R. Bonagura | Zendy; Frederick P. Siegal | Zendy; A. L. Abramson | Zendy; Frances SantiagoSchwarz | Zendy; Mary Ellen O’Reilly | Zendy; KM SHAH | Zendy; DOMENICA DRAKE | Zendy; Bettie M. Steinberg | Zendy

Open Access

Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis

Author(s) -

Vincent R. Bonagura,

Frederick P. Siegal,

A. L. Abramson,

Frances SantiagoSchwarz,

Mary Ellen O’Reilly,

KM SHAH,

DOMENICA DRAKE,

Bettie M. Steinberg

Publication year - 1994

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.1.3.357-360.1994

Subject(s) - immunology , major histocompatibility complex , human leukocyte antigen , recurrent respiratory papillomatosis , phenotype , immune system , biology , antigen , mhc class i , mhc class ii , papilloma , medicine , gene , genetics , pathology

Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate papillomavirus evasion of the cellular immune response.

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