Microbial Degradation of Sterols | Zendy

William J. Marsheck | Zendy; Stephen Kraychy | Zendy; R. D. Muir | Zendy

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Microbial Degradation of Sterols

Author(s) -

William J. Marsheck,

Stephen Kraychy,

R. D. Muir

Publication year - 1972

Publication title -

applied microbiology

Language(s) - English

Resource type - Journals

ISSN - 0003-6919

DOI - 10.1128/am.23.1.72-77.1972

Subject(s) - steroid , degradation (telecommunications) , microbial biodegradation , bacteria , mycobacterium , chemistry , ring (chemistry) , organic chemistry , biochemistry , biology , microorganism , telecommunications , hormone , computer science , genetics

A process is described for the microbial degradation of cholesterol and plant sterols, to produce androsta-1, 4-diene-3, 17-dione and androst-4-ene-3, 17-dione, by two newly isolated bacteria designatedMycobacterium sp. NRRL B-3683 andMycobacterium sp. NRRL B-3805. These myocbacteria produce substantial amounts of 17-ketonic compounds without appreciable degradation of the steroid nucleus. No ring degradation inhibitory agents are necessary. The first microbiological production of 20α-hydroxymethylpregna-1, 4-dien-3-one is also reported.

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