Drug Resistance as Influenced by Inactivated Sensitivity Discs | Zendy

Lewis J. Griffith | Zendy; C. G. Mullins | Zendy

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Drug Resistance as Influenced by Inactivated Sensitivity Discs

Author(s) -

Lewis J. Griffith,

C. G. Mullins

Publication year - 1968

Publication title -

applied microbiology

Language(s) - English

Resource type - Journals

ISSN - 0003-6919

DOI - 10.1128/am.16.4.656-658.1968

Subject(s) - cloxacillin , penicillin , humidity , antibiotics , microbiology and biotechnology , penicillin resistance , chemistry , biology , thermodynamics , physics

Reports of staphylococci resistant to the semisynthetic penicillins stimulated a study of the factors influencing the stability of the drugs in discs. The behavior of penicillin G, methicillin, oxacillin, cloxacillin, and cephalothin discs under different humidity and temperature conditions is described. Humidity was found to be the most significant factor in drug inactivation. Storage of discs in a vacuum desiccator at -20 C provides maximal antibiotic stability.

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