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6[d (—)-α-Guanidinophenylacetamido]-penicillanic acid was shown to be significantly hydrolyzed by only one of six preparations of staphylococcal penicillinase. This penicillin analogue is a stronger penicillinase inactivator than are nafcillin and methicillin, which were not significantly hydrolyzed by the enzyme.

Interaction of Staphylococcal Penicillinase and 6-[D(—)-α-Guanidino-Phenylacetamido]-Penicillanic Acid