Open AccessInteraction of Staphylococcal Penicillinase and 6-[D(—)-α-Guanidino-Phenylacetamido]-Penicillanic Acid
Author(s) -
Elizabeth H. Thiele,
Harry J. Robinson
Publication year - 1968
Publication title -
applied microbiology
Language(s) - English
Resource type - Journals
ISSN - 0003-6919
DOI - 10.1128/am.16.2.228-231.1968
Subject(s) - chemistry , nafcillin , penicillin , hydrolysis , enzyme , antibiotics , stereochemistry , biochemistry
6[d (—)-α-Guanidinophenylacetamido]-penicillanic acid was shown to be significantly hydrolyzed by only one of six preparations of staphylococcal penicillinase. This penicillin analogue is a stronger penicillinase inactivator than are nafcillin and methicillin, which were not significantly hydrolyzed by the enzyme.
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