Continuous Production of Clostridium tetani Toxin | Zendy

Bengt Zacharias | Zendy; Marianne Björklund | Zendy

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Continuous Production of Clostridium tetani Toxin

Author(s) -

Bengt Zacharias,

Marianne Björklund

Publication year - 1968

Publication title -

applied microbiology

Language(s) - English

Resource type - Journals

ISSN - 0003-6919

DOI - 10.1128/am.16.1.69-72.1968

Subject(s) - clostridium tetani , toxin , dilution , liter , potassium , chemistry , microbiology and biotechnology , biology , chromatography , tetanus , endocrinology , immunology , physics , vaccination , organic chemistry , thermodynamics

The continuous production ofClostridium tetani toxin has been carried out in a 1-liter stirred culture vessel for as long as 65 days. Toxin production of approximately 120 flocculating units per ml was maintained with a dilution rate of 0.125 hr-1 , a temperature of 34 C, ap H of 7.4, and the addition to the medium of 0.1 g of potassium chloride per liter. The average minimal lethal intraperitoneal dose of the toxin in mice was approximately 106 per ml.

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