Statolon-induced Resistance of Mice to Mengovirus | Zendy

Jerome P. Schmidt | Zendy; Frank F. Pindak | Zendy

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Statolon-induced Resistance of Mice to Mengovirus

Author(s) -

Jerome P. Schmidt,

Frank F. Pindak

Publication year - 1967

Publication title -

applied microbiology

Language(s) - English

Resource type - Journals

ISSN - 0003-6919

DOI - 10.1128/am.15.3.654-656.1967

Subject(s) - inoculation , intraperitoneal injection , virus , virology , medicine , immunology , pharmacology

Mice receiving statolon intraperitoneally were 1,000 times more resistant to intraperitoneal challenge with mengovirus than were untreated controls. Protection was afforded when statolon was administered 1 day before or 1 day after intraperitoneal inoculation with the virus. No therapeutic effect was observed when treatment with statolon was delayed for 2 days or more after virus infection. Exposure of mice to a simulated space cabin environment did not increase their susceptibility to the lethal effects of mengovirus infection or eliminate the protective effect of statolon.

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