Culture Conditions Control Expression of the Genes for Aflatoxin and Sterigmatocystin Biosynthesis in Aspergillus parasiticus and A. nidulans | Zendy

Feng Guo | Zendy; Thomas J. Leonard | Zendy

Open Access

Culture Conditions Control Expression of the Genes for Aflatoxin and Sterigmatocystin Biosynthesis in Aspergillus parasiticus and A. nidulans

Author(s) -

Feng Guo,

Thomas J. Leonard

Publication year - 1998

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.64.6.2275-2277.1998

Subject(s) - sterigmatocystin , aspergillus parasiticus , aspergillus nidulans , biology , polyketide synthase , aflatoxin , biosynthesis , gene , aspergillus flavus , patulin , mycotoxin , gene expression , biochemistry , microbiology and biotechnology , genetics , polyketide , botany , food science , mutant

High temperature and nitrate supported gene expression for sterigmatocystin biosynthesis inAspergillus nidulans ; ammonium did not. Homologous genes for aflatoxin biosynthesis inA. parasiticus showed the opposite transcript expression pattern, suggesting that the two mycotoxins are regulated differently. TheaflR gene is postulated to require additional genetic elements to effect its own activation by the different culture conditions. A patulin polyketide synthase (PKS) gene was found to be regulated differently than the aflatoxin PKS. Thus, the biosyntheses of structurally similar compounds in these two fungi appear to be regulated very differently.

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