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High temperature and nitrate supported gene expression for sterigmatocystin biosynthesis inAspergillus nidulans ; ammonium did not. Homologous genes for aflatoxin biosynthesis inA. parasiticus showed the opposite transcript expression pattern, suggesting that the two mycotoxins are regulated differently. TheaflR gene is postulated to require additional genetic elements to effect its own activation by the different culture conditions. A patulin polyketide synthase (PKS) gene was found to be regulated differently than the aflatoxin PKS. Thus, the biosyntheses of structurally similar compounds in these two fungi appear to be regulated very differently.

applied and environmental microbiology

Culture Conditions Control Expression of the Genes for Aflatoxin and Sterigmatocystin Biosynthesis in <i>Aspergillus parasiticus</i> and <i>A. nidulans</i>

Culture Conditions Control Expression of the Genes for Aflatoxin and Sterigmatocystin Biosynthesis in Aspergillus parasiticus and A. nidulans