Metabolism of verruculogen in rats | Zendy

K.P.W.C. Perera | Zendy; Brian J. Day | Zendy; Peter G. Mantle | Zendy; Leonardo Milani Avelar Rodrigues | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metabolism of verruculogen in rats

Author(s) -

K.P.W.C. Perera,

Brian J. Day,

Peter G. Mantle,

Leonardo Milani Avelar Rodrigues

Publication year - 1982

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.43.3.503-508.1982

Subject(s) - metabolism , perfusion , chemistry , liver metabolism , biochemistry , medicine

Radiolabeled verruculogen was detected in a wide range of body tissues 6 min after intravenous administration, but after a further 20 min it was mainly being excreted via the biliary route. In isolated liver perfusion, [14C]verruculogen was rapidly taken up by the liver and metabolized completely, principally to the related tremorgen TR-2 but also to a desoxy derivative of verruculogen. In addition, a smaller amount of an isomer of TR-2 was detected. These metabolic products were excreted in the bile.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research