Open AccessInfluence of tricarboxylic acid cycle intermediates and related metabolites on the biosynthesis of aflatoxin by resting cells of Aspergillus flavus
Author(s) -
T. Shantha,
V. Sreenivasa Murthy
Publication year - 1981
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.42.5.758-761.1981
Subject(s) - aflatoxin , aspergillus flavus , tricarboxylic acid , citric acid cycle , biochemistry , biosynthesis , cofactor , aspergillus , metabolism , chemistry , biology , microbiology and biotechnology , enzyme , food science
Resting cells of Aspergillus flavus synthesized aflatoxin from acetate as the sole carbon source after 36 h of incubation. Addition of pyruvate (5.5 mg/m) as cosubstrate to [1-14C]acetate and unlabeled acetate considerably reduced toxin production but increased the radioactivity on the tricarboxylic acid intermediates. This suggests that high tricarboxylic acid activity drastically affected toxin synthesis.
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