Mechanism of enteroviral inactivation by ozone | Zendy

D. Roy | Zendy; P.K.Y. Wong | Zendy; Richard S. Engelbrecht | Zendy; E Chian | Zendy

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Mechanism of enteroviral inactivation by ozone

Author(s) -

D. Roy,

P.K.Y. Wong,

Richard S. Engelbrecht,

E Chian

Publication year - 1981

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.41.3.718-723.1981

Subject(s) - poliovirus , ozone , virus , nucleic acid , rna , virology , infectivity , chemistry , biology , bacteriophage ms2 , viral envelope , microbiology and biotechnology , coat protein , biochemistry , gene , organic chemistry

The mechanism of enteroviral inactivation by ozone was investigated with poliovirus 1 (Mahoney) as the model virus. Ozone was observed to alter two of the four polypeptide chains present in the viral protein coat of poliovirus 1. However, the alteration of the protein coat did not significantly impair virus adsorption or alter the integrity of the virus particle. Damage to the viral RNA after exposure to ozone was demonstrated by velocity sedimentation analysis. It was concluded that the damage to the viral nucleic acid is the major cause of poliovirus 1 inactivation by ozone.

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