Fumitoxins, new mycotoxins from Aspergillus fumigatus Fres
Author(s) -
J P Debeaupuis,
P. Lafont
Publication year - 1978
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.36.1.8-10.1978
Subject(s) - aspergillus fumigatus , mycotoxin , microbiology and biotechnology , aspergillus , chemistry , fungi imperfecti , biology , mass spectrometry , chromatography , food science
Extracts of cultures of Aspergillus fumigatus isolated from silage were lethal to chicken embryos. Using this test and thin-layer chromatography, four UV-absorbing toxins, designated as fumitoxins A, B, C and D, were isolated. Analysis and mass spectrometry of crystallized fumitoxin A, the most abundant in the extract, established its molecular formula to be C31H42O8. Infrared, UV spectroscopy, and chemical reactions suggested that fumitoxin A is a steroid. Fumitoxins appear to be clearly different from the previously described toxins recognized in A. fumigatus.
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