Inactivation of enteroviruses by ascorbic acid and sodium bisulfite | Zendy

Richard J. Salo | Zendy; Dean O. Cliver | Zendy

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Inactivation of enteroviruses by ascorbic acid and sodium bisulfite

Author(s) -

Richard J. Salo,

Dean O. Cliver

Publication year - 1978

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.36.1.68-75.1978

Subject(s) - ascorbic acid , sodium bisulfite , poliovirus , chemistry , echovirus , bisulfite , coxsackievirus , infectivity , biochemistry , sodium ascorbate , sodium , virus , microbiology and biotechnology , virology , biology , enterovirus , food science , organic chemistry , gene expression , gene , dna methylation

Poliovirus type 1, coxsackievirus type A9, and echovirus type 7 were inactivated by sodium bisulfite and ascorbic acid. Inactivation rates depended upon concentration, temperature, and pH. RNA infectivity was lost during inactivation; the capsid was also altered by these inactivating agents, as determined by enzyme sensitivity assays and by tests of adsorption to cells. Structural modifications of the virus particles were not identical, suggesting that the mechanism of inactivation by ascorbic acid differs from that of sodium bisulfite.

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