Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes | Zendy

C. A. Claridge | Zendy; H Schmitz | Zendy

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Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes

Author(s) -

C. A. Claridge,

H Schmitz

Publication year - 1978

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.36.1.63-67.1978

Subject(s) - mucor , acinetobacter calcoaceticus , streptomyces griseus , chemistry , streptomyces , hydrolysis , cytotoxicity , biotransformation , microorganism , acinetobacter , antifungal , microbiology and biotechnology , basidiomycota , bacteria , biochemistry , stereochemistry , biology , organic chemistry , botany , food science , penicillium , enzyme , in vitro , antibiotics , genetics

Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.

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