Acute toxicity of 12,13-epoxytrichothecenes in one-day-old broiler chicks | Zendy

Thomas S. Robison | Zendy; C. J. Mirocha | Zendy; K.R. Reddy | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Acute toxicity of 12,13-epoxytrichothecenes in one-day-old broiler chicks

Author(s) -

Thomas S. Robison,

C. J. Mirocha,

K.R. Reddy

Publication year - 1978

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.35.4.636-640.1978

Subject(s) - diacetoxyscirpenol , broiler , toxin , dosing , toxicity , trichothecene , acute toxicity , median lethal dose , zoology , body weight , potency , weight gain , toxicology , chemistry , biology , pharmacology , medicine , microbiology and biotechnology , biochemistry , in vitro

Acute toxic effects of several 12,13-epoxytrichothecenes were investigated in 1-day-old broiler chicks by single oral doses. The 7-day median lethal dose values of purified 8-acetylneosolaniol, diacetoxyscirpenol, T-2 toxin, HT-2 toxin, neosolaniol, deacetyl-HT-2 toxin, and T-2 tetraol were 3.22 +/- 0.26, 3.82 +/- 0.40, 4.97 +/- 0.44, 7.22 +/- 0.39, 24.87 +/- 2.64, 30.18 +/- 7.53 (incomplete value), and 33.79 +/- 5.39 mg/kg of body weight, respectively. Deaths occurred during the 8- to 60-h period after dosing with the tested trichothecenes. Within 4 to 10 h after dosing, inappetence, asthenia, diarrhea, and coma generally developed. Sublethal doses of each toxin decreased feed consumption and weight gain proportionally with the amounts of toxins administered. These results demonstrate that the toxic potency of 12,13-epoxytrichothecenes varies depending on the modification of side chains in the molecule.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research