Open AccessDisruption of c-di-GMP Signaling Networks Unlocks Cryptic Expression of Secondary Metabolites during Biofilm Growth in Burkholderia pseudomallei
Author(s) -
Grace I. Borlee,
Mihnea R. Mangalea,
Kevin H. Martin,
Brooke A. Plumley,
Samuel J. Golon,
Bradley R. Borlee
Publication year - 2022
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.02431-21
Subject(s) - burkholderia pseudomallei , biofilm , microbiology and biotechnology , biology , bacteria , burkholderia , genetics
Burkholderia pseudomallei is a saprophytic bacterium residing in the environment that switches to a pathogenic lifestyle during infection of a wide range of hosts. The environmental cues that serve as the stimulus to trigger this change are largely unknown.