Open AccessMbnC Is Not Required for the Formation of the N-Terminal Oxazolone in the Methanobactin from Methylosinus trichosporium OB3b
Author(s) -
Philip Dershwitz,
Wenyu Gu,
Julien Roche,
Christina S. Kang-Yun,
Jeremy D. Semrau,
Thomas A. Bobik,
Bruce Fulton,
Hans Zischka,
Alan A. DiSpirito
Publication year - 2022
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.01841-21
Subject(s) - chemistry , oxazolone , dipeptide , thioamide , mutant , stereochemistry , operon , biochemistry , gene , peptide
A number of environmental and medical applications have been proposed for MBs, including bioremediation of toxic metals and nanoparticle formation, as well as the treatment of copper- and iron-related diseases. However, before MBs can be modified and optimized for any specific application, the biosynthetic pathway for MB production must be defined.