Open AccessThe Yeast eIF2 Kinase Gcn2 Facilitates H 2 O 2 -Mediated Feedback Inhibition of Both Protein Synthesis and Endoplasmic Reticulum Oxidative Folding during Recombinant Protein Production
Author(s) -
Veronica Gast,
Kate Campbell,
Cecilia Picazo,
Martin K. M. Engqvist,
Verena Siewers,
Mikael Molin
Publication year - 2021
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.00301-21
Subject(s) - endoplasmic reticulum , unfolded protein response , biochemistry , protein biosynthesis , biology , protein disulfide isomerase , saccharomyces cerevisiae , microbiology and biotechnology , chemistry , yeast
Recombinant protein production is a multibillion dollar industry. Optimizing the productivity of host cells is, therefore, of great interest.