Detection of SARS-CoV-2 Variants Mu, Beta, Gamma, Lambda, Delta, Alpha, and Omicron in Wastewater Settled Solids Using Mutation-Specific Assays Is Associated with Regional Detection of Variants in Clinical Samples | Zendy

Marlene K. Wolfe | Zendy; Bridgette Hughes | Zendy; Dorothea Duong | Zendy; Vikram Chan-Herur | Zendy; Krista R. Wigginton | Zendy; Bradley J. White | Zendy; Alexandria B. Boehm | Zendy

Open Access

Detection of SARS-CoV-2 Variants Mu, Beta, Gamma, Lambda, Delta, Alpha, and Omicron in Wastewater Settled Solids Using Mutation-Specific Assays Is Associated with Regional Detection of Variants in Clinical Samples

Author(s) -

Marlene K. Wolfe,

Bridgette Hughes,

Dorothea Duong,

Vikram Chan-Herur,

Krista R. Wigginton,

Bradley J. White,

Alexandria B. Boehm

Publication year - 2022

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00045-22

Subject(s) - wastewater , biology , covid-19 , pandemic , digital polymerase chain reaction , virology , gene , genetics , medicine , polymerase chain reaction , environmental science , environmental engineering , infectious disease (medical specialty) , disease

Wastewater represents a pooled biological sample of the contributing community and thus a resource for assessing community health. Here, we show that emergence, spread, and disappearance of SARS-CoV-2 infections caused by variants of concern are reflected in the presence of variant genomic RNA in wastewater settled solids. This work highlights an important public health use case for wastewater.

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