Open AccessFluconazole Penetration into the Pancreas
Author(s) -
Shailesh V. Shrikhande,
Helmut Friess,
Claudia Issenegger,
M. E. Martigi,
Yong Huang,
Beat Gloor,
R A Yeates,
Jörg Kleeff,
Markus W. Büchler
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.9.2569-2571.2000
Subject(s) - fluconazole , pancreas , pancreatitis , penetration (warfare) , necrosis , acute pancreatitis , superinfection , medicine , pancreatic disease , gastroenterology , antibiotics , microbiology and biotechnology , pathology , biology , antifungal , immunology , virus , operations research , engineering
Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 μg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.