Open AccessComparative In Vitro Activities of Ertapenem (MK-0826) against 1,001 Anaerobes Isolated from Human Intra-Abdominal Infections
Author(s) -
Ellie J. C. Goldstein,
Diane M. Citron,
C. Vreni Merriam,
Yumi A. Warren,
Kerin L. Tyrrell
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.9.2389-2394.2000
Subject(s) - ertapenem , bacteroides fragilis , microbiology and biotechnology , agar dilution method , agar dilution , bacteroides , biology , in vitro , agar , bacteria , antimicrobial , antibiotics , imipenem , minimum inhibitory concentration , antibiotic resistance , biochemistry , genetics
By using an agar dilution method, the comparative in vitro activities of ertapenem (MK-0826) were studied against 1,001 anaerobes isolated from human intra-abdominal infections in 17 countries worldwide. MK-0826 was uniformly active against all isolates, including allBacteroides fragilis group species isolates, with the exception of 12 of 61 (20%) strains ofBilophila wadsworthia , 3 strains of lactobacilli, and 1 isolate ofAcidaminococcus fermentans . Geographical variation in activity was not observed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom