In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans | Zendy

Joseph Meletiadis | Zendy; Johan W. Mouton | Zendy; Juan L. Rodrı́guez-Tudela | Zendy; Jacques F. Meis | Zendy; Paul E. Verweij | Zendy

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In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans

Author(s) -

Joseph Meletiadis,

Johan W. Mouton,

Juan L. Rodrı́guez-Tudela,

Jacques F. Meis,

Paul E. Verweij

Publication year - 2000

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.44.2.470-472.2000

Subject(s) - terbinafine , itraconazole , checkerboard , broth microdilution , microbiology and biotechnology , pharmacology , antagonism , minimum inhibitory concentration , biology , antifungal , medicine , antibiotics , genetics , receptor

In order to develop new approaches for the chemotherapy of invasive infections caused byScedosporium prolificans , the in vitro interaction between itraconazole and terbinafine against 20 clinical isolates was studied using a checkerboard microdilution method. Itraconazole and terbinafine alone were inactive against most isolates, but the combination was synergistic against 95 and 85% of isolates after 48 and 72 h of incubation, respectively. Antagonism was not observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.

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