Open AccessIn Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans
Author(s) -
Joseph Meletiadis,
Johan W. Mouton,
Juan Luis Rodríguez-Tudela,
Jacques F. Meis,
Paul E. Verweij
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.2.470-472.2000
Subject(s) - terbinafine , itraconazole , checkerboard , broth microdilution , microbiology and biotechnology , pharmacology , antagonism , minimum inhibitory concentration , biology , antifungal , medicine , antibiotics , genetics , receptor
In order to develop new approaches for the chemotherapy of invasive infections caused byScedosporium prolificans , the in vitro interaction between itraconazole and terbinafine against 20 clinical isolates was studied using a checkerboard microdilution method. Itraconazole and terbinafine alone were inactive against most isolates, but the combination was synergistic against 95 and 85% of isolates after 48 and 72 h of incubation, respectively. Antagonism was not observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.