Open AccessHeterogeneity of AmpC Cephalosporinases of Hafnia alvei Clinical Isolates Expressing Inducible or Constitutive Ceftazidime Resistance Phenotypes
Author(s) -
Delphine Girlich,
Thierry Naas,
Samuel Bellais,
Laurent Poirel,
A. Karim,
Patrice Nordmann
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.11.3220-3223.2000
Subject(s) - ceftazidime , phenotype , biology , microbiology and biotechnology , gene , hafnia , bacteria , genetics , chemistry , cubic zirconia , ceramic , organic chemistry , pseudomonas aeruginosa
Ten unrelatedHafnia alvei clinical isolates were grouped according to either their low-level and inducible cephalosporinase production or their high-level and constitutive cephalosporinase production phenotype. Their AmpC sequences shared 85 to 100% amino acid identity. The immediate genetic environment ofampC genes was conserved inH. alvei isolates but was different from that found in otherampC -possessing enterobacterial species.