Open AccessImpact of Flavophospholipol and Vancomycin on Conjugational Transfer of Vancomycin Resistance Plasmids
Author(s) -
Sabine Riedl,
Knut Ohlsen,
Guido Werner,
Wolfgang Witte,
Jörg Hacker
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.11.3189-3192.2000
Subject(s) - plasmid , vancomycin , enterococcus faecium , microbiology and biotechnology , enterococcus , biology , operon , bacteria , antibiotics , staphylococcus aureus , escherichia coli , genetics , gene
The influence of vancomycin and flavophospholipol (FPL) on the transfer rate of conjugative plasmids harboring the vancomycin resistance operonvanA was determined in several clinical and animal isolates ofEnterococcus faecium . FPL significantly inhibited the frequency of transfer of conjugative VanA plasmids up to 70-fold. Vancomycin had no significant effect on the transfer rate of VanA plasmids.