Open AccessEffect of Subinhibitory Concentrations of Macrolides on Expression of Flagellin inPseudomonas aeruginosaandProteus mirabilis
Author(s) -
Kumiko Kawamura-Sato,
Yoshitsugu Iinuma,
Tadao Hasegawa,
Toshinobu Horii,
Takafumi Yamashino,
Michio Ohta
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.10.2869-2872.2000
Subject(s) - proteus mirabilis , flagellin , microbiology and biotechnology , azithromycin , pseudomonas aeruginosa , erythromycin , biology , clarithromycin , minimum inhibitory concentration , antibacterial agent , antibiotics , bacteria , genetics
In the present study we showed by molecular analysis that the inhibition of motility by macrolides inProteus mirabilis andPseudomonas aeruginosa was well correlated with the loss of the expression of flagellin. Erythromycin, clarithromycin, and azithromycin at subinhibitory concentrations (sub-MICs) suppressed the expression of flagellin dose dependently. Azithromycin had the strongest inhibitory effect on the expression ofP. aeruginosa flagellin, whereas 16-membered rokitamycin had only a weak inhibitory effect. These results indicate the potential effectiveness of sub-MICs of erythromycin, clarithromycin, and azithromycin for the treatment of patients withP. mirabilis andP. aeruginosa infections.