Trovafloxacin Concentrations in Airway Fluids of Patients with Severe Community-Acquired Pneumonia | Zendy

Renaat Peleman | Zendy; Vera Van de Velde | Zendy; Paul Germonpré | Zendy; C. Fleurinck | Zendy; M.T. Rosseel | Zendy; Ruben Pauwels | Zendy

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Trovafloxacin Concentrations in Airway Fluids of Patients with Severe Community-Acquired Pneumonia

Author(s) -

Renaat Peleman,

Vera Van de Velde,

Paul Germonpré,

C. Fleurinck,

M.T. Rosseel,

Ruben Pauwels

Publication year - 2000

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.44.1.178-180.2000

Subject(s) - liter , trovafloxacin , bronchoalveolar lavage , sputum , pneumonia , medicine , respiratory disease , airway , anesthesia , gastroenterology , antibacterial agent , microbiology and biotechnology , antibiotics , lung , pathology , biology , tuberculosis

The penetration of trovafloxacin (TVA), 200 mg once daily, into the airways of 17 patients with severe pneumonia was studied. The mean (standard deviations are given in parentheses) steady-state TVA concentrations, 2 h after the last intake, were 3.1 (0.3) mg/liter in induced sputum (n = 8), 3.2 (1.1) mg/liter in bronchial secretions (n = 9), 3.2 (0.9) mg/liter in bronchoalveolar lavage fluid (n = 10), and 4.9 (1.4) mg/liter in epithelial lining fluid (n = 11).

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