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We compared the in vitro activity of BMS-207147, an investigational triazole, with those of itraconazole and fluconazole against 613 clinical bloodstream isolates ofCandida spp. collected from SENTRY participating hospitals during 1997 and 1998. Overall, BMS-207147 was the most active azole against allCandida spp. While both BMS-207147 and itraconazole displayed a stepwise decrease in activity against isolates for which the fluconazole MICs were elevated, BMS-207147 had two- to fourfold greater activity than itraconazole both againstCandida spp. that were dose-dependently fluconazole susceptible and against those that were fluconazole resistant.

antimicrobial agents and chemotherapy

In Vitro Activities of BMS-207147 against Over 600 Contemporary Clinical Bloodstream Isolates of <i>Candida</i> Species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America

In Vitro Activities of BMS-207147 against Over 600 Contemporary Clinical Bloodstream Isolates of Candida Species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America