Open AccessPenetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients
Author(s) -
Markus Müller,
Martin Brunner,
Ursula Hollenstein,
Christian Joukhadar,
Rainer Schmid,
Erich Minar,
H Ehringer,
Hans Georg Eichler
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.8.2056
Subject(s) - ciprofloxacin , microdialysis , penetration (warfare) , diabetes mellitus , medicine , interstitial fluid , inflammation , endocrinology , interstitial space , area under the curve , antibiotics , urology , biology , microbiology and biotechnology , operations research , engineering , central nervous system
Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0.2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curveinfection /area under the concentration-time curveunaffected tissue = 0.99 ± 0.15 [mean ± standard error],n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue.