Comparative In Vitro Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Klebsiella pneumoniae , Klebsiella oxytoca , Enterobacter cloacae , and Enterobacter aerogenes Clinical Isolates with Alterations in GyrA and ParC Proteins | Zendy

Sylvain Brisse | Zendy; D. Milatović | Zendy; Ad C. Fluit | Zendy; J. Verhoef | Zendy; Nele Martin | Zendy; Sybille Scheuring | Zendy; Karl Köhrer | Zendy; FranzJosef Schmitz | Zendy

Open Access

Comparative In Vitro Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Klebsiella pneumoniae , Klebsiella oxytoca , Enterobacter cloacae , and Enterobacter aerogenes Clinical Isolates with Alterations in GyrA and ParC Proteins

Author(s) -

Sylvain Brisse,

D. Milatović,

Ad C. Fluit,

J. Verhoef,

Nele Martin,

Sybille Scheuring,

Karl Köhrer,

FranzJosef Schmitz

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.8.2051

Subject(s) - enterobacter aerogenes , trovafloxacin , microbiology and biotechnology , klebsiella pneumoniae , klebsiella oxytoca , enterobacter cloacae , ciprofloxacin , moxifloxacin , gatifloxacin , klebsiella , levofloxacin , enterobacter , antibacterial agent , biology , antibiotics , escherichia coli , biochemistry , gene

The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates ofKlebsiella pneumoniae ,Klebsiella oxytoca ,Enterobacter cloacae , andEnterobacter aerogenes . Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested againstK. pneumoniae andE. aerogenes .

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