Improvement of In Vitro and In Vivo Antileishmanial Activities of 2′,6′-Dihydroxy-4′-Methoxychalcone by Entrapment in Poly( d,l -Lactide) Nanoparticles | Zendy

Eduardo Caio Torres-Santos | Zendy; J. M. Rodrigues | Zendy; Davyson de Lima Moreira | Zendy; Maria Auxiliadora Coelho Kaplan | Zendy; Bartira RossiBergmann | Zendy

Open Access

Improvement of In Vitro and In Vivo Antileishmanial Activities of 2′,6′-Dihydroxy-4′-Methoxychalcone by Entrapment in Poly( d,l -Lactide) Nanoparticles

Author(s) -

Eduardo Caio Torres-Santos,

J. M. Rodrigues,

Davyson de Lima Moreira,

Maria Auxiliadora Coelho Kaplan,

Bartira RossiBergmann

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.7.1776

Subject(s) - in vivo , in vitro , leishmaniasis , nanoparticle , chemistry , pharmacology , leishmania , intracellular , biochemistry , biology , immunology , nanotechnology , materials science , parasite hosting , microbiology and biotechnology , world wide web , computer science

The inhibition of intracellularLeishmania amazonensis growth by 2′,6′-dihydroxy-4′-methoxychalcone (DMC) isolated fromPiper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.

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