Open AccesspncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis Isolates from Northwestern Russia
Author(s) -
Harri Marttila,
Merja Marjamäki,
Elena Vyshnevskaya,
Boris Vyshnevskiy,
Tatiana Otten,
Alexandr V. Vasilyef,
Matti K. Viljanen
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.7.1764
Subject(s) - pyrazinamide , mycobacterium tuberculosis , microbiology and biotechnology , genotype , mutation , tuberculosis , biology , gene , virology , genetics , medicine , pathology
Thirty-six pyrazinamide-resistant and eight pyrazinamide-susceptibleMycobacterium tuberculosis isolates from Russia were analyzed for theirpncA mutations. Thirty-one (86.1%) of the resistant isolates had a mutation either inpncA or upstream of the gene. Twenty of the 23 different mutations found in this study had not been described earlier.pncA genotype correlated well with pyrazinamidase activity and BACTEC 460 susceptibility test results.