Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues | Zendy

Martin Brunner | Zendy; Ursula Hollenstein | Zendy; Simon Delacher | Zendy; Dorothea Jäger | Zendy; Rainer Schmid | Zendy; Edith Lackner | Zendy; Apostoulos Georgopoulos | Zendy; Hans Georg Eichler | Zendy; Markus Müller | Zendy

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Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues

Author(s) -

Martin Brunner,

Ursula Hollenstein,

Simon Delacher,

Dorothea Jäger,

Rainer Schmid,

Edith Lackner,

Apostoulos Georgopoulos,

Hans Georg Eichler,

Markus Müller

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.5.1307

Subject(s) - ciprofloxacin , pharmacokinetics , microdialysis , antimicrobial , pharmacology , distribution (mathematics) , antibiotics , in vitro , drug , antibacterial agent , chemistry , medicine , biology , microbiology and biotechnology , biochemistry , mathematical analysis , mathematics , central nervous system

Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.

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