Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae | Zendy

Kimberly Bergman | Zendy; Keith M. Olsen | Zendy; Tom E. Peddicord | Zendy; Paul D. Fey | Zendy; Mark E. Rupp | Zendy

Open Access

Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae

Author(s) -

Kimberly Bergman,

Keith M. Olsen,

Tom E. Peddicord,

Paul D. Fey,

Mark E. Rupp

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.5.1291

Subject(s) - clarithromycin , streptococcus pneumoniae , haemophilus influenzae , azithromycin , microbiology and biotechnology , antimicrobial , potency , antibacterial agent , haemophilus , pasteurellaceae , biology , antibiotics , bacteria , in vitro , biochemistry , genetics

The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin againstStreptococcus pneumoniae . Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin againstHaemophilus influenzae . Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

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