β-Lactamase Production and Antimicrobial Susceptibility of Oral Heterogeneous Fusobacterium nucleatum Populations in Young Children | Zendy

Eija Könönen | Zendy; A. Kanervo | Zendy; K. Salminen | Zendy; Hannele Jousimies–Somer | Zendy

Open Access

β-Lactamase Production and Antimicrobial Susceptibility of Oral Heterogeneous Fusobacterium nucleatum Populations in Young Children

Author(s) -

Eija Könönen,

A. Kanervo,

K. Salminen,

Hannele Jousimies–Somer

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.5.1270

Subject(s) - fusobacterium nucleatum , microbiology and biotechnology , penicillin , amoxicillin , trovafloxacin , antimicrobial , clavulanic acid , biology , antibiotics , antibacterial agent , bacteria , porphyromonas gingivalis , genetics

OralFusobacterium nucleatum populations from 20 young, healthy children were examined for β-lactamase production. Ten children (50%) harbored, altogether, 25 β-lactamase-positiveF. nucleatum isolates that were identified asF. nucleatum subsp.polymorphum ,F. nucleatum subsp.nucleatum , andF. nucleatum subsp.vincentii (J. L. Dzink, M. T. Sheenan, and S. S. Socransky, Int. J. Syst. Bacteriol. 40:74–78, 1990). In vitro susceptibility of these β-lactamase-producing and 26 non-β-lactamase-producingF. nucleatum isolates was tested with penicillin G, amoxicillin-clavulanic acid, tetracycline hydrochloride, metronidazole, trovafloxacin, and azithromycin. Except for penicillin G, the antimicrobials exhibited good activity against allF. nucleatum isolates.

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