Potentiation of Isoniazid Activity againstMycobacterium tuberculosisby Melatonin | Zendy

Ian Wiid | Zendy; Eileen G. Hoal | Zendy; Dinie Hon | Zendy; Carl Lombard | Zendy; Paul D. van Helden | Zendy

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Potentiation of Isoniazid Activity againstMycobacterium tuberculosisby Melatonin

Author(s) -

Ian Wiid,

Eileen G. Hoal,

Dinie Hon,

Carl Lombard,

Paul D. van Helden

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.4.975

Subject(s) - isoniazid , melatonin , tuberculosis , mycobacterium tuberculosis , long term potentiation , medicine , pharmacology , immunology , biology , pathology , receptor

The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.

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