Lactic Acid Polymers as Biodegradable Carriers of Fluoroquinolones: An In Vitro Study | Zendy

Kyriaki Kanellakopoulou | Zendy; Maria Kolia | Zendy; Antonios Anastassiadis | Zendy; Themistoklis Korakis | Zendy; Evangelos J. GiamarellosBourboulis | Zendy; A. G. Andreopoulos | Zendy; Eleftherios Dounis | Zendy; Helen Giamarellou | Zendy

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Lactic Acid Polymers as Biodegradable Carriers of Fluoroquinolones: An In Vitro Study

Author(s) -

Kyriaki Kanellakopoulou,

Maria Kolia,

Antonios Anastassiadis,

Themistoklis Korakis,

Evangelos J. GiamarellosBourboulis,

A. G. Andreopoulos,

Eleftherios Dounis,

Helen Giamarellou

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.3.714

Subject(s) - pefloxacin , in vitro , biodegradable polymer , lactic acid , ciprofloxacin , polymer , chemistry , microbiology and biotechnology , ofloxacin , pharmacology , medicine , antibiotics , bacteria , biochemistry , biology , organic chemistry , genetics

A biodegradable polymer ofdl -dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.

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