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The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producingHaemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producingH. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance ofH. influenzae , HMR 3004 was more effective (P &lt; 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.

Ketolide Treatment of Haemophilus influenzae Experimental Pneumonia