Multiplex Sequence Analysis Demonstrates the Competitive Growth Advantage of the A-to-G Mutants of Clarithromycin-Resistant Helicobacter pylori | Zendy

Ge Wang | Zendy; M. Sayeedur Rahman | Zendy; M. Zafri Humayun | Zendy; Diane E. Taylor | Zendy

Open Access

Multiplex Sequence Analysis Demonstrates the Competitive Growth Advantage of the A-to-G Mutants of Clarithromycin-Resistant Helicobacter pylori

Author(s) -

Ge Wang,

M. Sayeedur Rahman,

M. Zafri Humayun,

Diane E. Taylor

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.3.683

Subject(s) - clarithromycin , 23s ribosomal rna , mutant , helicobacter pylori , biology , point mutation , mutation , multiplex , microbiology and biotechnology , genetics , gene , rna , ribosome

Clarithromycin resistance inHelicobacter pylori is due to point mutation within the 23S rRNA. We examined the growth rates of different types of site-directed mutants and demonstrated quantitatively the competitive growth advantage of A-to-G mutants over other types of mutants by a multiplex sequencing assay. The results provide a rational explanation of why A-to-G mutants are predominantly observed among clarithromycin-resistant clinical isolates.

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