In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs | Zendy

Bruno Pradines | Zendy; Adama Tall | Zendy; Thierry Fusaı̈ | Zendy; André Spiegel | Zendy; Rémi Hienne | Zendy; Christophe Rogier | Zendy; J F Trape | Zendy; Jacques Le Bras | Zendy; Daniel Parzy | Zendy

Open Access

In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

Author(s) -

Bruno Pradines,

Adama Tall,

Thierry Fusaı̈,

André Spiegel,

Rémi Hienne,

Christophe Rogier,

J F Trape,

Jacques Le Bras,

Daniel Parzy

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.418

Subject(s) - amodiaquine , chloroquine , plasmodium falciparum , artemether , pyrimethamine , quinine , malaria , drug resistance , pharmacology , biology , cross resistance , in vitro , traditional medicine , virology , medicine , microbiology and biotechnology , artemisinin , immunology , biochemistry

The 50% inhibitory concentration (IC50 s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.

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