Mycobacteriocidal Action of Exogenous Nitric Oxide | Zendy

Richard Long | Zendy; Bruce Light | Zendy; James Talbot | Zendy

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Mycobacteriocidal Action of Exogenous Nitric Oxide

Author(s) -

Richard Long,

Bruce Light,

James Talbot

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.403

Subject(s) - nitric oxide , extracellular , mycobacterium tuberculosis , microbiology and biotechnology , tuberculosis , bacteria , bacilli , chemistry , medicine , pharmacology , biology , biochemistry , pathology , genetics

We tested the hypothesis that exposure of extracellular Mycobacterium tuberculosis to low concentrations (< 100 ppm) of nitric oxide (NO) for short periods (24 h or less) will result in microbial killing. We observed that NO had both dose- and time-dependent cidal effects that were very significant by two-way analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively). Conceivably, extracellular bacilli in patients with pulmonary tuberculosis might be vulnerable to exogenous NO.

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