Diversification of Escherichia coli Expressing an SHV-Type Extended-Spectrum β-Lactamase (ESBL) during a Hospital Outbreak: Emergence of an ESBL-Hyperproducing Strain Resistant to Expanded-Spectrum Cephalosporins | Zendy

Andrzej Pałucha | Zendy; B Mikiewicz | Zendy; Marek Gniadkowski | Zendy

Open Access

Diversification of Escherichia coli Expressing an SHV-Type Extended-Spectrum β-Lactamase (ESBL) during a Hospital Outbreak: Emergence of an ESBL-Hyperproducing Strain Resistant to Expanded-Spectrum Cephalosporins

Author(s) -

Andrzej Pałucha,

B Mikiewicz,

Marek Gniadkowski

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.393

Subject(s) - cephalosporin , escherichia coli , microbiology and biotechnology , beta lactamase , antibiotics , biology , outbreak , enterobacteriaceae , virology , cefotaxime , broad spectrum , gene , chemistry , genetics , combinatorial chemistry

Twelve SHV-type extended-spectrum β-lactamase (ESBL)-producingEscherichia coli lac mutant isolates were recovered in October 1997 from 11 patients of the neonatal ward in a Warsaw hospital. The outbreak was clonal; however, some of the isolates expressed a much higher level of resistance to several β-lactam antibiotics, including expanded-spectrum cephalosporins. This phenotype has been attributed to β-lactamase hyperproduction correlating with the multiplication of ESBL gene copies, as was demonstrated for representative isolates.

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