Antimicrobial Resistance of 1,113 Streptococcus pneumoniae Isolates from Patients with Respiratory Tract Infections in Spain: Results of a 1-Year (1996–1997) Multicenter Surveillance Study | Zendy

Fernando Baquero | Zendy; José Ángel Garcı́a-Rodrı́guez | Zendy; Juan García de Lomas | Zendy; Lorenzo Aguilar | Zendy

Open Access

Antimicrobial Resistance of 1,113 Streptococcus pneumoniae Isolates from Patients with Respiratory Tract Infections in Spain: Results of a 1-Year (1996–1997) Multicenter Surveillance Study

Author(s) -

Fernando Baquero,

José Ángel Garcı́a-Rodrı́guez,

Juan García de Lomas,

Lorenzo Aguilar

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.357

Subject(s) - cefuroxime , cefotaxime , streptococcus pneumoniae , penicillin , microbiology and biotechnology , ceftriaxone , cephalosporin , respiratory tract infections , antibiotics , pneumococcal infections , antibiotic resistance , medicine , antibacterial agent , biology , respiratory system

A nationwide susceptibility surveillance of 1,113Streptococcus pneumoniae isolates was carried out and found the following percentages of resistance: cefuroxime, 46%; penicillin, 37%; macrolides, 33%; aminopenicillins, 24%; cefotaxime, 13%; and ceftriaxone, 8%. A significant(P < 0.05) seasonality pattern for β-lactam antibiotics was observed. Resistance to macrolides was higher(P < 0.05) in middle-ear samples. Higher percentages of resistance to cefuroxime and macrolides were observed among penicillin-intermediate and -resistant strains, whereas high frequencies of resistance to aminopenicillins and expanded-spectrum cephalosporins were observed only among penicillin-resistant strains.

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