Distribution of the cfiA Gene among Bacteroides fragilis Strains in Japan and Relatedness of cfiA to Imipenem Resistance | Zendy

Kikuo Yamazoe | Zendy; Naoki Kato | Zendy; Haru Kato | Zendy; Kaori Tanaka | Zendy; Yoshihiro Katagiri | Zendy; Kunitomo Watanabe | Zendy

Open Access

Distribution of the cfiA Gene among Bacteroides fragilis Strains in Japan and Relatedness of cfiA to Imipenem Resistance

Author(s) -

Kikuo Yamazoe,

Naoki Kato,

Haru Kato,

Kaori Tanaka,

Yoshihiro Katagiri,

Kunitomo Watanabe

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.11.2808

Subject(s) - bacteroides fragilis , imipenem , microbiology and biotechnology , biology , bacteroidaceae , gene , antibiotics , genetics , antibiotic resistance , bacteria

ThecfiA gene, encoding an imipenem-hydrolyzing metallo-β-lactamase produced byBacteroides fragilis , and insertion-like elements were detected by PCR amplification withB. fragilis strains isolated in Japan. ThecfiA gene was found in 1.9 and 4.1% of the imipenem-susceptibleB. fragilis isolates collected from 1987 to 1988 and from 1992 to 1994, respectively. Insertion-like elements adjacent to thecfiA gene were found in all nine metallo-β-lactamase-producing imipenem-resistant strains tested but not in ninecfiA -positive strains with no detectable metallo-β-lactamase activity.

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