Open AccessDistribution of the cfiA Gene among Bacteroides fragilis Strains in Japan and Relatedness of cfiA to Imipenem Resistance
Author(s) -
Kikuo Yamazoe,
Naoya Kato,
Haru Kato,
Kaori Tanaka,
Yuki Katagiri,
Kunitomo Watanabe
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.11.2808
Subject(s) - bacteroides fragilis , imipenem , microbiology and biotechnology , biology , bacteroidaceae , gene , antibiotics , genetics , antibiotic resistance , bacteria
ThecfiA gene, encoding an imipenem-hydrolyzing metallo-β-lactamase produced byBacteroides fragilis , and insertion-like elements were detected by PCR amplification withB. fragilis strains isolated in Japan. ThecfiA gene was found in 1.9 and 4.1% of the imipenem-susceptibleB. fragilis isolates collected from 1987 to 1988 and from 1992 to 1994, respectively. Insertion-like elements adjacent to thecfiA gene were found in all nine metallo-β-lactamase-producing imipenem-resistant strains tested but not in ninecfiA -positive strains with no detectable metallo-β-lactamase activity.