Activities of Telithromycin (HMR 3647, RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Other Antimicrobial Agents against Unusual Anaerobes | Zendy

Ellie J. C. Goldstein | Zendy; Diane M. Citron | Zendy; C. Vreni Merriam | Zendy; Yumi A. Warren | Zendy; Kerin L. Tyrrell | Zendy

Open Access

Activities of Telithromycin (HMR 3647, RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Other Antimicrobial Agents against Unusual Anaerobes

Author(s) -

Ellie J. C. Goldstein,

Diane M. Citron,

C. Vreni Merriam,

Yumi A. Warren,

Kerin L. Tyrrell

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.11.2801

Subject(s) - microbiology and biotechnology , telithromycin , bacteroides , peptostreptococcus , roxithromycin , fusobacterium , biology , prevotella , prevotella intermedia , agar dilution , actinomyces , anaerobic bacteria , clarithromycin , erythromycin , actinomyces israelii , antibacterial agent , porphyromonas gingivalis , antimicrobial , antibiotics , bacteria , minimum inhibitory concentration , genetics

The comparative activity of telithromycin (HMR 3647) against 419 human anaerobic isolates was determined by the agar dilution method. At concentrations of ≤0.5 μg/ml, telithromycin was active againstActinomyces israelii ,Actinomyces odontolyticus ,Bacteroides tectum ,Bacteroides ureolyticus ,Bacteroides gracilis (nowCampylobacter gracilis ),Porphyromonas spp. (includingPorphyromonas gingivalis andPorphyromonas macacae ),Prevotella intermedia ,Prevotella heparinolytica , and almost allPeptostreptococcus species. Clostridia showed species and strain variability, often with a biphasic pattern.Fusobacterium species, exceptFusobacterium russii , were relatively resistant.

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