In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp | Zendy

Dermot Kenny | Zendy; Paul F. Russell | Zendy; Deborah Rogers | Zendy; S. M. Eley | Zendy; Richard W. Titball | Zendy

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In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp

Author(s) -

Dermot Kenny,

Paul F. Russell,

Deborah Rogers,

S. M. Eley,

Richard W. Titball

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.11.2773

Subject(s) - burkholderia pseudomallei , melioidosis , microbiology and biotechnology , burkholderia , ceftazidime , imipenem , ciprofloxacin , antibiotics , biology , gentamicin , burkholderia cepacia complex , bacteria , antibiotic resistance , pseudomonas aeruginosa , genetics

The in vitro antimicrobial susceptibilities of isolates ofBurkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities ofBurkholderia pseudomallei andBurkholderia cepacia . The antibiotic susceptibility profile ofB. mallei resembled that ofB. pseudomallei more closely than that ofB. cepacia , which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against bothB. mallei andB. pseudomallei . Gentamicin was active againstB. mallei but not againstB. pseudomallei . Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.

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