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The in vitro antimicrobial susceptibilities of isolates ofBurkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities ofBurkholderia pseudomallei andBurkholderia cepacia . The antibiotic susceptibility profile ofB. mallei resembled that ofB. pseudomallei more closely than that ofB. cepacia , which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against bothB. mallei andB. pseudomallei . Gentamicin was active againstB. mallei but not againstB. pseudomallei . Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.

In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp