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Postantibiotic Effects of Gatifloxacin against Gram-Positive and -Negative Organisms
Author(s) -
Glenn A. Pankuch,
Michael R. Jacobs,
Peter C. Appelbaum
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.10.2574
Subject(s) - gatifloxacin , pseudomonas aeruginosa , microbiology and biotechnology , staphylococcus aureus , escherichia coli , streptococcus pneumoniae , gram , enterococcus , klebsiella pneumoniae , biology , chemistry , bacteria , antibiotics , levofloxacin , biochemistry , genetics , gene
Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. ForEscherichia coli andPseudomonas aeruginosa , PAEs were 2.2 to 4.8 h. Pneumococcal, staphylococcal, and enterococcal postantibiotic sub-MIC effects (PA-SMEs) (four times the MICs) were 3.7 to 8.6, 2.3 to 3.8, and 1.6 h, respectively, andE. coli andP. aeruginosa PA-SMEs were ≥9.6 and 4.4 h, respectively.

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