Drug Efflux and parC Mutations Are Involved in Fluoroquinolone Resistance in Viridans Group Streptococci | Zendy

María-José Ferrándiz | Zendy; Jesús Oteo | Zendy; Belén Aracil | Zendy; José Luís Gómez-Garcés | Zendy; Adela G. de la Campa | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Drug Efflux and parC Mutations Are Involved in Fluoroquinolone Resistance in Viridans Group Streptococci

Author(s) -

María-José Ferrándiz,

Jesús Oteo,

Belén Aracil,

José Luís Gómez-Garcés,

Adela G. de la Campa

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.10.2520

Subject(s) - efflux , ciprofloxacin , biology , microbiology and biotechnology , viridans streptococci , gene , genetics , drug resistance , streptococcaceae , streptococcus , antibiotics , bacteria

Nine ciprofloxacin-resistant viridans group streptococci isolated from asymptomatic carriers were analyzed. Identification to the species level by using three different commercial systems and a PCR-based approach was inconsistent. The nucleotide sequences of fragments of theparC ,parE ,gyrA , andgyrB genes showed considerable intra- and interspecies variations, and these variations mainly involved silent mutations. Three isolates had changes in Ser-79 of ParC (to Phe or Tyr). Phenotypic characterization indicated that eight of the nine isolates had a putative efflux mechanism that would confer low-level resistance to ciprofloxacin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research