In Vitro Activities of Six New Fluoroquinolones against Brucella melitensis | Zendy

I. Trujillano-Martín | Zendy; Enrique García-Sánchez | Zendy; I. Martínez | Zendy; Marı́a José Fresnadillo | Zendy; José Elías GarcíaSánchez | Zendy; José Ángel Garcı́a-Rodrı́guez | Zendy

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In Vitro Activities of Six New Fluoroquinolones against Brucella melitensis

Author(s) -

I. Trujillano-Martín,

Enrique García-Sánchez,

I. Martínez,

Marı́a José Fresnadillo,

José Elías GarcíaSánchez,

José Ángel Garcı́a-Rodrı́guez

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.1.194

Subject(s) - gatifloxacin , ofloxacin , moxifloxacin , ciprofloxacin , trovafloxacin , levofloxacin , brucella melitensis , microbiology and biotechnology , antibacterial agent , minimum inhibitory concentration , pharmacology , chemistry , brucella , medicine , antibiotics , biology , virology , brucellosis

We have tested the in vitro activities of eight fluoroquinolones against 160Brucella melitensis strains. The most active was sitafloxacin (MIC at which 90% of the isolates are inhibited [MIC90 ], 0.12 μg/ml). In decreasing order, the activities (MIC90 s) of the rest of the tested fluoroquinolones were as follows: levofloxacin, 0.5 μg/ml; ciprofloxacin, trovafloxacin, and moxifloxacin, 1 μg/ml; and ofloxacin, grepafloxacin, and gatifloxacin, 2 μg/ml.

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