Control of Candida albicans Murine Vaginitis by Topical Administration of Polycarbophil-Econazole Complex | Zendy

Emilia Ghelardi | Zendy; Arianna Tavanti | Zendy; Antonella Lupetti | Zendy; Francesco Celandroni | Zendy; Enrico Boldrini | Zendy; M. Campa | Zendy; Sonia Senesi | Zendy

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Control of Candida albicans Murine Vaginitis by Topical Administration of Polycarbophil-Econazole Complex

Author(s) -

Emilia Ghelardi,

Arianna Tavanti,

Antonella Lupetti,

Francesco Celandroni,

Enrico Boldrini,

M. Campa,

Sonia Senesi

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.9.2434

Subject(s) - econazole , candida albicans , vaginitis , medicine , pharmacology , microbiology and biotechnology , mycosis , miconazole , dermatology , immunology , biology , gynecology , antifungal

The complexation of econazole with the mucoadhesive polycarbophil was found to significantly improve the therapeutic benefit of the drug in the topical treatment of experimental vaginal candidiasis in mice, while no difference in the antimycotic activity exerted by econazole and polycarbophil-econazole could be detected in vitro.

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